Depends on how you use it, but that link posted above gives a general idea for just serving. I've seen that in an ideal situation, carbing/serving used roughly 1/2lb of co2. So, a 10lber would last for about 20 kegs. But as mentioned, a lot of people use them for other things like cleaning/sanitizing etc. I'm still dialing in my system and have been chasing small leaks, but am noticing about 1lb of co2 per keg.