I have two CO2 systems here at my house. A 20# that runs my kegerator, with three 5 gal kegs inside. the Tank sits outside the frig, line runs thru side of the frig to a manifold, so I can turn off individual kegs when I want to. Only time I do that is if I am carbonating one, and then I turn the pressure up in the whole system, and only turn on the one that is getting the 'treatment'.
The other tank is a 5#, which I use for my beer gun, and for initial pressurization and carbonation of newly filled kegs. This unfortunate regulator sustained damage once upon a time, when it got knocked to the floor, while attached to a 5# gas tank. That damaged the low pressure gauge, necessitating replacement of that gauge. The regulator still leaks, very slowly. If I leave that one turned on, I will go through a 5# tank in about two weeks.
This regulator used to be attached to the 20# system, and I was needing to get a refill there about every four weeks. That was a hassle, as the 'gas store' is clear across town, and it's a bit of a hassle for me to get up there. On a hunch, I switched regulators between the two systems, and the loss problem on the 20# system stopped.
Right now, I live with the situation as it is. I generally don't keep the 5# system charged, as its use is intermittent. HAving said that, it is charged right now, as I am force carbonating a keg in my newly acquired keezer, getting it ready for a party this weekend, when I will have to transport the carbonated keg to the party. It will be wrapped in a keg parka, and I will need to get a refill on my 5# tank, so that I am ready for dispensing.
Right now, I cannot justify replacing the regulator, just to fix this inconvenient leakage problem. I have replaced the broken gauge, but the leak problem persists. I have checked for leaks at the tank connection, and it's not there. I suspect that there is a leak somewhere in the regulator, perhaps in the replacement gauge. Used plumber's tape when I mounted the new gauge. That's about all I know to do. Beyond that, I am resigned to living with the situation.