I grew up on Orange County and now call San Diego my home.
Head down to Pizza Port in San Clemente, it's about 20 mins south of Laguna and still in Orange County.
If you plan on hitting Stone, consider:
Lost Abbey
Green Flash
Heading farther south, you could hit Ballast Point and Alesmith, both not to be missed
Heading farther south and east and really like IPAs, head out to Alpine Beer Co. It's a very long haul from Laguna but they make possibly one of the best IPAs you can get. You can barely get the beer in San Diego, they have a brewpub for food. Just to be warned, Alpine isn't much and the brewery is tiny.
If you are pressed for time, just head to O'Briens pub in San Diego, you can get most of the local brews on tap.