I listen to one of three on a daily basis, all for different reasons:
Basic Brewing Radio
Topic: Generally everything, never gets too advanced, hence 'basic brewing'.
The Good: After answering emails, it's pretty much all business and they are relatively short, so you don't get a lot of information that's too in depth for the given topic.
The Bad: Sometimes I question the opinions and expertise of the 'experts' James brings on the show, although he brings on John Palmer quite often which is awesome.
Sunday Session (Brewing Network)
Topic: Everything, both relevant to beer and completely irrelevant.
The Good: Pretty entertaining, gets more in depth than Basic Brewing. Very Long.
The Bad: Tons of banter, I'd say actual on-topic beer talk is less than 50%. Sometimes too long, haha.
Jamil Show (Brewing Network)
Topic: Each episode is a Beer style and Jamil gives a great recipe that correlates with it.
The good: Chock full of into. On average, The side banter is probably less than the rest of the shows and is usually semi-relevant anyways. Jamil is a god among homebrewers.
The bad: To hear Jamil's thoughts on something other than styles and recipes you'll have to go to the Sunday Show where he makes appearances.