I like to keep it relatively simple with:
93% Gambrinus ESB (or your favorite 2 row), 5% Crystal 40, and 2% carapils and ferment with a clean yeast that accentuates hops. Something like 1056, wlp001, or us05.
For the hops I usually do 60, 20, and 0 min additions. I try to aim for about 20 IBU...