San Diego
- Good beer
- Great weather
- Lots of other stuff to do, places to eat or to just sit around looking at the scenery.
I'd stay in the Mission Beach area, as it's pretty central and well, it's on the beach.
The only issue with San Diego is how spread out it is and the almost utter lack of public transportation. For example, Stone Brewery and Ballast Point are about a 40 min drive away from each other, but still are still in the same county.
Funny, I was just there for business/pleasure and went to those breweries in the same day. I went to Ballast first and it was more my style. Smaller and more personal but both were awesome. Oh, and I stayed in Mission Beach.