So as far as I can tell....a reasonable practice to use acid with RO water is to put the acid in once mashed in? Otherwise the ph of the mash water could fall too low due to the lack of buffering? Before mashing in, adding and properly dissolving salts and taking a ph reading will help in predicting the amount of acid needed to add to the mash?
As AJ mentioned, definitely DON'T add acid to the mash since its very difficult to evenly distribute it. Add the precalculated amounts of acid and minerals to the strike water and stir the water well. That will assure those constituents are well-distributed.
With that acid addition in RO or distilled water, the strike water's pH may fall very low (maybe into the 4 range). That is an appropriate result and its not something to worry about. The buffers in the malt will raise the wort pH back into your intended range.
Don't try and chase wort pH by mashing in and then measuring. You are far better off with targeting a mash pH with software derived mineral and acid additions and then monitoring the resulting mash pH to see if the target for future batches needs to be adjusted up or down to meet your wort pH goal.