I use both 6 and 6.5 glass carboys. Doesn't matter too much, but the bit of extra room in the 6.5 is nice.
What DOES matter is that you always use a blow-off tube. I use the 3.5 foot section of one inch ID tubing that Northern Brewer sells for a few bucks and route it to a pickle jar with water in it. The tubing fits right into the neck of the carboy for an airtight seal. After the Krausen has dropped, I switch to a standard airlock bubbler.
The question is not IF you will have a blow-off, but WHEN? I get two or three a year.
Pez.
EDIT - Ahhh, the above poster just said the same thing as I, but in less words.