No opinion on AA vs. Detroit when it comes to lodging, other than to agree that if you can find a place in AA, bars and restaurants are probably more walkable than in Detroit. But don't let any worries about "safety" deter you from staying in Detroit. In the areas where you'll be, it'll be fine.
On your way from AA to Detroit, stop at Cultivate in Ypsilanti for a beer and some great coffee and a cool beer garden. Look for the plaque that has TalkBeer on it and tell Ryan that Brian sent you. He'll also have Schramm's bottles for sale and other cool bottles as well possibly cans from Transient. He'll crowler anything from their excellent tap list for you, too.
In Detroit, I'd recommend beer at Founders and beer and pizza at Jolly Pumpkin. Very close to each other, with 8 Degrees Plato in between for some bottle shopping. If the Tigers are in town, tickets will indeed be cheap from any scalper you may find. Comerica isn't too far from JP and Founders. There's also Batch, in a different section of the city. I'm not huge on their beer, but lots of folks like it and I hear all sorts of good reports on the food. And you should go to American or Lafayette and have coneys while you're here.
There's absolutely no reason whatsoever to go to Kuhnhenn. The beer hasn't been good for years and there's nothing there I can think of that would be interesting or fun for the kids. Avoid.
As for Schramm's, it's probably the last kid-friendly place I can think of. It's basically a wine tasting room. It's fine for what it is, but I wouldn't bother taking kids there. B Nektar is probably a better option as far as the space goes, but I wouldn't bother with either if I was you. Just get some bottles somewhere and call it good.
And, if you're in Kalamazoo, you have to go to Bell's. The food is fantastic (Jambalaya!) and there's no better beer experience than super fresh Two Hearted on tap. They'll also have a bunch of taproom only beers and maybe a surprise or two.
Minor league baseball--Mud Hens in Toledo.
rpbuckeye can help you out with Toledo recs.
Shoot me a PM and I'll try and get away for a beer. Enjoy your trip!