Anderson, SC has a brewery downtown called Carolina Bauernhaus Ales. I don't think dogs can come into the brewery unless it is a service animal. I may be wrong about that though. They have a tap room and there is a yeast company housed there as well (SouthYeast Labs) that focuses on yeast...
Just Brew It Anderson is located in Anderson. We meet the 1st Wednesday of the month at Carolina Bauernhaus. If you have any questions let me know. There is a club in Clemson, the Clemson Brew Crew, but I think it is associated with University. I'm not sure if the club in Greenville is still...
I've been to service brewing and moon river in Savannah. Both are decent. Service didn't allow anyone under 21 in the building, so it you have kids you may want to avoid.
I only keep 4-5 strains around at a time. I've tried keeping more than that but I find they just sit around and never get used. Only 2 regulars and then 2 that I rotate around every 3 batches or so.