You need to know the starting gravity to be able to use a refractometer once the yeast has begun to produce alcohol. Refractometers are calibrated to be used where the liquid solution is water not alcohol so to obtain a meaningful reading the amount of alcohol in the solution needs to be factored in. Knowing what the starting gravity was and what the current reading when run through a set of formulae accounts for this. But if you know the fruit you are fermenting and the amount of water /sugar (if appropriate ) you added you can usually come up with a reasonable starting gravity(most table fruit when pressed will produce a juice at about 1.045, 1 lb of sugar adds 40 points to a gallon of water and ripe wine grapes (I believe) have a brix of about 21 or a gravity of about 1.090.