Well, if you want a local beer geek's opinion, here it is:
Big Dogs Draft House is the best local brewery by quite a ways. Unfortunately right now their best beers are not available (War Dog and Alpha Dog). However, tomorrow (10/27/2011) night they will be having a tapping party for their new pumpkin ale. As they are the best brewery in town, I am a big fan. The ambiance isn't anywhere as cool as a California brewery/brewpub, but hey this is Vegas, we don't have culture here. The place should be hopping for the tapping.
Tenaya Creek and Joseph James are next on the ladder for beer brewed here, but Joseph James is just a brewery and not a pub. Joseph James does a tour every third Saturday of the month, so you will be missing that. I would skip the other breweries.
If you are looking for good beer bars, the best in town by far is Aces and Ales. Best craft beer in town, and on Monday they will be tapping DFH Bitches Brew.
The real secret in town is Wednesday nights at Khoury's Fine Wine and Spirits. We have a beer lover's get together from 6-9 at this very fine bottle shop. Bring something, or buy something off of the shelf to share. They have a serving license, so you can sit and drink, and a food truck will be there to serve some fine food to go with your beer. I just got done sharing a Cascade Brewing 2010 Kriek at Khoury's! Also had a 2008 Bouron County Stout that was delicious!
Here's an up to date answer that you will normally get if you were to post this on BA:
http://beeradvocate.com/forum/read/4147351