Against the grain is very good, beer and food. Quite a few breweries spread out through the city. Just across the bridge in southern Indiana, there is flat12 brew works, they don't have a lot in the way of food, but always have a great lineup of their beers on tap. A few miles west, in new albany, is Floyd county brewing, great food, and a smaller, but still good, tap list. Also in new albany, but further away from the river, is New albanian brewing, they have great pizza and a long list of their own beers as well as beers from tons of other brewers.