Well first I agree that hop blending is the way to go in terms of adding depth to the beer. Unless youre looking to play around and explore how particular hop varietals perform.
Otherwise, regarding biotransformation, my understanding is that its more about the timing of the hop addition...
Been using lupulin powder quite a bit in our APAs recently, including the lactose IPA (www.brewersfriend.com/homebrew/recipe/view/533033/hash-ketchum-milkshake-ipa) that is currently in the kegerator.
Ditto regarding the temporary burn after kegging and the recommended usage ratio. I know...