That's the whole idea behind the OSU High-alpha hop breeding program. I use Columbus pellets most of the time. Widmer makes a bittering blend called Amalgam and uses it in most of their brews.
I wouldn't try using Columbus in a recipe calling for Noble hops, but otherwise...
Remember one unassailable statistic, as explained by the late, great George Carlin: "Just think of how stupid the average person is, and then realize half of them are even stupider!"
"I would like to die on Mars, just not on impact." Elon Musk