Go across the river (I-65 to I-265W, then take the Grant Line Rd exit, left at the light, then left at the Pizza Hut) to Richo's/New Albanian Brewery.
It's, maybe, 25 mins or a half hour from Louisville. Well worth the drive. Sit in the pub side, not the Sportstime Pizza side.
Try the NABC sampler. I was there a few days ago and they have Beak's Best ESB on tap again after a long absence. Give it a try. (Delerium Tremens on tap too.)
Downtown, The Pub (on 4th Street) is decent but pretty commercial (they do have a few good brews though, including Fuller's ESB, on tap). And try the fried pickle spears.
Browning's at Slugger Field is good. Try the Browning's She-Devil IPA. I haven't eaten there, but the food does look good.
Cumberland Brews is spoken highly of, but I've never been able to get in there; parking isn't easy and it's always been packed. Maybe a weekday night would work.
Edit: I just looked at your profile and see you must be fond of Belgians. Definitely hit Richo's, in that case. There's a good selection of Belgians on tap.