I've only ever been to the Ram which is right in the middle of downtown Indy.
Good food, good beer.
Here's a site that lists more of the current brewpubs.
There's a great homebrew shop on the NE side of town, Great Fermentations.
Bottled/Kegged/Conditioning: Orfy's Boddington's clone, Orfy's Old Speckled Hen clone, SN Celebration clone
On Deck: Gumballhead clone, German Pilsner
Drinking: Old Ale, Bourbon Barrel Wee Heavy, Bourbon Barrel RIS