"Form Follows Function". This is the golden rule in engineering design: Things look the way they do because they work better than other designs.
I don't see labels in any of your layouts. I have no idea what any of the buttons or displays actually do.
I would suggest, however, that you do indeed label them so that you -- or anyone -- can look at your board and see what's being done or monitored.
That said, I also suggest that you group things according to function. I wouldn't put a temperature readout right next to a flowmeter between two voltage displays. Group like-items together. Don't worry about symmetry or how pretty it is: you want to get pertinent information in a single glance, without having to search all over the board for it.