Any time during the boil. If you compared adding it at 5 and at 60, there would be a very slight reduction in the bittering due to the higher gravity. But, it's down in the noise.
Remember one unassailable statistic, as explained by the late, great George Carlin: "Just think of how stupid the average person is, and then realize half of them are even stupider!"
"I would like to die on Mars, just not on impact." Elon Musk