You can spray StarSan in the outer portions before you hook up the drain hose, and the inner part is boiled in the kettle. Your only worry is the inside of the ball, right? (assuming a ball valve here)
I recirculate for a whirlpool so everything gets boiling wort sanitized, but if not I would probably just spray everything with StarSan that I could, pitch plenty of yeast, and RDWHAHB.
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