IBU Contribution (Tinseth) calculated as:
IBU = (U X AA% X W X 7490) / (V X C)
Where:
U = utilization = BF X BTF
BF = 1.65 X 0.000125^(wort gravity-1)
BTF = (1-exp(-0.04 X time mins))/4.15
AA% = decimal % alpha acids in hops used
W = weight in ounces of hops
V = gallons of wort
C = Gravity correction = 1 + [(Gboil - 1.050) / 0.2]
Add 10% IBU for pellet vs. leaf hops
From: Designing Great Beers, Ray Daniels
Do the IBU contribution calc for each hop addition, then add 'em all up.