I considered copper on my rig, but decided against it. I'm glad I did. I wouldn't trade my silicone with QD's for anything. Here's a few advantages for silicone:
1.) If you have trouble getting a pump to prime, you can just detach it, lower it, and let gravity help you.
2.) You can see what's happening. Don't discount the visibility too much. I think it's pretty important. It helps to know where the liquid is when priming a pump.
3.) You can easily change your mind about how things are run with soft tubing. It is so easy to move liquid around between any of the vessels when you can just reattach the QD's anywhere.
4.) In 30 seconds, my tubing is disconnected and hanging to dry. This also allows my pumps to be open and dry.
5.) Much less heat loss during a recirculation, if that is an issue to for you. Although you could insulate copper, I suppose.