The difference will be in the flow rate through the chiller. You will be using more water with the 1/2" tubing. If you could regulate the flow to be the same in both chillers, then the 3/8" tubing would chill a bit faster because of turbulence in the tubing. Smaller diameter would equate to a faster flow, and therefore more turbulence. Regardless of diameter, I would not use anything shorter than 20-25 feet. Isn't 1/2" a lot harder to bend? Consider that.
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