The problem is that 5 gallons ferments at a very different rate than 4 ounces. It's an interesting thing to do but inaccurate for home brewers.
As long as you sanitize your equipment, there isn't really much risk to taking a sample. I don't take a ton of readings. I leave my beers in the primary for a least 4 weeks so I take a reading when it's going into the primary and other before I containerize just to be sure it's finished.
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Batch 1 Brewing
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