I all depends on the yeast strain!
I used to ferment with Cal ale at 60, but it would underattenuate, at least for me. I bet others have had success with it at low temps. If you are using an English strain it will most likely flocculate, they are pretty sensitive to temperature fluctuation. A good strain to use at lower temps is German ale, it will give you clean, lager like ales, if you don't mind the minimal esters.
Other than that, you have to experiment and see what works well, if it works for someone one way it might not work out the same for you. So give it a try and see what happens.