I've heard many people talk about it but in all my years of brewing, I don't think I've ever tasted anything that I would describe as "twang."
I've had great AG beers, and really bad ones (the kind where you conceal a grimace at a tasting and choke out an insincere "Wow, this is good') and great and bad extract beers.
I'm not saying it's a myth but I will say that there are hundreds or thousands of uncontrolled variables in every brew batch that could account for a unique-ness in the flavors.
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