Extract brewing doesn't benefit as much from a clarifying agent (like Whirlfloc or Irish Moss) as does all-grain, but it can still help a little bit with beer clarity in the extract process. I've used both, in extract and AG, and prefer to use it...especially in lighter beers where you expect more clarity. I have not experienced any ill effects from it's use, for what it's worth. It's pretty much essential for me these days, since I've converted to AG.
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