I've done this with Simcoe and 2-row and had one of my best beers, although I've only been brewing for about 8 months. To my surprise, I found that Simcoe wasn't available at my LHBS a couple weeks ago, so I decided to use Cascade for the same (this is now in my primary). I used the same hop schedule and hope to produce another good beer.
For a hoppy IPA type, which I assume you're shooting for, try doing a first wort hop addition (search threads if you're not sure of this). Then do a 20, 15, 10, 5, and 0 minute addition, followed by some good dry hops.
This is only my opinion, but I was not disappointed with my Simcoe SMaSH. Next, I'll be trying the same with Amarillo.
Maverick Moon Miner Brewing