Yes, 1 line goes from the regulator to the side of the manifold, 2-3 lines go from the check valves pointing down to your kegs. You can shut any or all off and change pressure on one or more as long as you have check valves. Make sure you use teflon tape and check for leaks. I ordered one that was pre-assembled and had a slight leak. I tightened it and fixed the problem.
I also ordered a wye splitter to add a 4th keg on mine for a one time use (my wedding). the check valves on the manifold are too close together for the wye splitter to fit parallel with the manifold, so for not it is turned 90 degrees perpendicular.