I agree with Jeffjm, Perennial is going to be the unique, rarer styles, and fantastic place to go. I'd say, make sure you go there and four hands. Urban chestnut and Civil life are right there...don't know if they bottle. I have been to six-row a few times...good food but better beer elsewhere. For bbq, Pappy's is fantastic and I've heard Bogart's smokehouse is right there. For dessert, Ted Drewes frozen custard and/or Crown candy. Crown is a really cool, old-fashioned candy and ice cream shop, but not necessarily in the best neighborhood (but not the worst St. Louis has to offer). If you are there when the Cards are (hopefully) playing, head down to the landing (it's a strip of bars/restaurants down by the Mississippi) for a good crowd and experience. And food on The Hill is going to be a good Italian dining option anywhere you go. Those are my favorites when I am back home! Enjoy!