You probably wouldn't get into an anchor tour. I hear they are always full.
21st has good beers, but not too much to see there. Heretic brewing is in the northwest part of town, if you are a Jamil fan you might catch him there. I've heard great things about Magnolia, but I've never been.
Russian River is less than an hour north, Santa Rosa. That's where I'd go. I've been there, all the beers are superb.