while not many people seem to like it a ton, 21st amendment is one of my favorite brewpubs. great food and good beer. check em out next time you're in town, the hop crisis double IPA is killer and their biere de garde is pretty good too. rogue ales is in north beach too, and definitely try to get on a tour of anchor next time as well.
almost forgot about thirsty bear. all organic brewpub that serves tapas as well.