The Hilton for downtown and for a nice hotel, Campbell House is B+B and not very close to many breweries or nightlife. The downtown nightlife is sketchy, but you can get anywhere from downtown easily. The breweries are in West Eugene and that area is kinda sketchy too. Better to travel to visit. Your other options for beer are the Bier Stein (great bottle shop and beer bar with 30 taps) and Falling Sky Brewing (also a homebrew shop, brew tons of styles of beer with interesting ingredients, and have food) South of downtown.