The last batch I brewed, I tasted throughout the fermentation process via a spigot on my fermenter (as to not introduce O2). Day 1-4: delicious. By about day 6, after the Krausen had fallen back through the beer, the taste completely changed. I don't know if this was a coincidence or not, but I believe it developed some astringent off flavors from the krausen.
I have an IPA going right now that I have skimmed twice (with a star-san sanitized utensil) and so far so good. I'm at about day 7 and no strange smell/flavor yet. I'll report my findings when primary is complete.
Anyone else skim the yeast during primary or is this generally a bad practice?