I'm not sure how others do it, but being a bit OCD and approaching all things in life as a scientist, here's what I'm doing:
1) Establish a simple pale ale recipe that I know I like, using only one type of hop.
2) Brew it over and over again, changing nothing but the hop used.
3) Bottoms up.
I'll probably apply something similar to different yeast strains somewhere down the road. Granted, it'll take a while, but patience is part of the homebrew game.
Take it easy,