I will be visiting Charleston, SC in a couple weeks. Looking for a HB shop to visit while in town.
There are really no home brew shops here, but we do have a few good breweries that you can visit.
Coast http://www.coastbrewing.com/ (helped change laws in the state)
Westbrook http://westbrookbrewing.blogspot.com/ (just opened and web page is outdated)
Plus here are a few brew pubs and good bars on N. King street.
This is a great town and enjoy your stay.