Calculated IBUS, for the most part, are real IBUS. Your tongue physically cannot distinguish between 100 IBU, 110 IBU, or 3000 IBU. There's also a limit on the solubility of isomerized alpha acids, but that's not really important- a 200 IBU beer and a 100 IBU beer taste the same. As for variety of bittering hops, you absolutely boil off all of the flavor and aroma contributors, so if you're looking for the big IBUs, just grab your highest alpha hop. If you're looking for a certain "quality" of bitterness, try comparing different Alpha acid/beta acid ratios, and beta acid levels.
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Monticello Barleywine, Red Nosed Tripel
Cali Common, Imperial Common, Sunshine Belgian Rye, Sticke Note Alt
Cherry Blackberry melomel
Belma Pale Ale, Cluster Fug IIPA, American IIPA v1.0, rauchbier, roggenbier