Do it! I had the chance to try the same wort that was fermented with 5 different strains, including Brett. by Mikellier (spelling?) last year. It was like a pale ale wort, and then they did a lager strain, and english bitter strain, the Brett, a hefeweizen strain, and I can't quite remember the last yeast used, but you could very distinctly tell them apart. was very cool.
Primary: English Mild
On tap: Pale Ale, Lancelot's Wheat, English Brown Ale, Steam Beer, HoovNuts IPA
Bottled: MOAM, Braggot, Raspberry Melomel, Merlot, Apfelwein, Pyment, Sweet mead, Cabernet
Gal in 2009: 27, Gal in 2010: 34, Gal in 2011: 13, Gal in 2012: 10