Water chemistry of the
world (not really) has a chart of the water chemistry of some of the great brewing cities of Europe. Burton has extremely hard water, Pilsen very soft. If you start with RO water and make a pilsner, you wouldn't make any adjustments. Don't kow what style Burton is famous for, but at least one reference talks about "sulphur overtones".
Decide on the style you are going to brew, look up where it originated and adjust.
You will probably need yeast nutrient for pilsners, as RO water has none available.