I guess it depends on what you want. First, I would say go with DME and do late extract addition. Otherwise, you'll end up with a pretty dark hefe. Also, I don't know if you want to add orange juice to a boil. I think that might result in some pretty rough flavors. I would pasteurize it and then add it to primary or secondary. Finally make sure you like late hop additions in your hefes. I do, but many don't.
Oh and I like 3068 because it provides awesome flavors and aromas. I let the yeast do most of the talking for this brew.