you will inevitably receive something from that amount it may not be bitterness but just he presence of that many will effect the beer.
I like late hopped beer so I usually try to get 50% of the bitterness from the first addition and the rest at the end of the boil.
In the case of my last brew
2oz in the mash
2oz at 85
4oz at 15
4oz at 5
4oz at 0
going to be good
On tap: #79 Berliner Weisse 1.030 9/20/12, Flanders, Barleywine, Wild Blonde (1.045 blonde hopped up and fermented with WLP644), #80B rett Saison
Fermenting: #82 Galaxy IPA, #83 Black IPA
Aging: #67 Bareleywine 1.116 11/07/2012, Flanders 2 batches 1.056 and 1.060 12/12/11 and 3/26/12, Kriek, 1.052 12/11,