you will inevitably receive something from that amount it may not be bitterness but just he presence of that many will effect the beer.
I like late hopped beer so I usually try to get 50% of the bitterness from the first addition and the rest at the end of the boil.
In the case of my last brew
2oz in the mash
2oz at 85
4oz at 15
4oz at 5
4oz at 0
going to be good 
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On tap: #72 flower power Saison 1.053>1.004 with lavender and jasmine, experimental sour 1.072 > 1.000, #73 Pale Ale 1.063 > 1.012, #71 French IPA, American IPA with spanish cedar and fermented with 3711 1.059>1.008
Fermenting: Aging: #67 Bareleywine 1.116 11/07/2012, Flanders 2 batches 1.056 and 1.060 12/12/11 and 3/26/12, Smoked Porter 1.063 10/11, pepper RIS 1.088 7/11, Kriek, 1.052 12/11, RYE IPA sour experiment 8/12, Berliner Weisse 1.030 9/20/12
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